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The effect of aging on the repeated-dose liver micronucleus assay using diethylnitrosamine

BACKGROUND: The repeated-dose liver micronucleus (RDLMN) assay has been well-developed and applied because of its simplicity and the ease of integration into general toxicity studies which is the preferred method from the 3R’s point of view. In this assay, we observed micronucleated hepatocytes whic...

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Detalles Bibliográficos
Autores principales: Satomoto, Kensuke, Suzuki, Isamu, Mita, Koji, Wakita, Atsushi, Yamagata, Hiroshi, Mitsumoto, Tatsuya, Hamada, Shuichi
Formato: Online Artículo Texto
Lenguaje:English
Publicado: BioMed Central 2022
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9387043/
https://www.ncbi.nlm.nih.gov/pubmed/35982479
http://dx.doi.org/10.1186/s41021-022-00250-5