Interfering with nucleotide excision by the coronavirus 3’-to-5’ exoribonuclease

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Some of the most efficacious antiviral therapeutics are ribonucleos(t)ide analogs. The presence of a 3’-to-5’ proofreading exoribonuclease (ExoN) in coronaviruses diminishes the potency of many ribonucleotide analogs. The ability to interfere with ExoN activity will create new possibilities for cont...

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Detalles Bibliográficos
Autores principales: Chinthapatla, Rukesh, Sotoudegan, Mohamad, Anderson, Thomas, Moustafa, Ibrahim M., Passow, Kellan T., Kennelly, Samantha A., Moorthy, Ramkumar, Dulin, David, Feng, Joy Y., Harki, Daniel A., Kirchdoerfer, Robert, Cameron, Craig E., Arnold, Jamie J.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Cold Spring Harbor Laboratory 2022
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9387131/
https://www.ncbi.nlm.nih.gov/pubmed/35982684
http://dx.doi.org/10.1101/2022.08.11.503614

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9387131/
https://www.ncbi.nlm.nih.gov/pubmed/35982684
http://dx.doi.org/10.1101/2022.08.11.503614

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