Viral Kinetics of Severe Acute Respiratory Syndrome Coronavirus 2 (SARS-CoV-2) Omicron Infection in mRNA-Vaccinated Individuals Treated and Not Treated with Nirmatrelvir-Ritonavir

We measured viral kinetics of SARS-CoV-2 Omicron infection in 36 mRNA-vaccinated individuals, 11 of whom were treated with nirmatrelvir-ritonavir (NMV-r). We found that NMV-r was associated with greater incidence of viral rebound compared to no treatment. For those that did not rebound, NMV-r signif...

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Autores principales: Dai, Eric Y., Lee, Kannon A., Nathanson, Audrey B., Leonelli, Ariana T., Petros, Brittany A., Brock-Fisher, Taylor, Dobbins, Sabrina T., MacInnis, Bronwyn L., Capone, Amelia, Littlehale, Nancy, Boucau, Julie, Marino, Caitlin, Barczak, Amy K., Sabeti, Pardis C., Springer, Michael, Stephenson, Kathryn E.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Cold Spring Harbor Laboratory 2022
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9387148/
https://www.ncbi.nlm.nih.gov/pubmed/35982651
http://dx.doi.org/10.1101/2022.08.04.22278378
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author Dai, Eric Y.
Lee, Kannon A.
Nathanson, Audrey B.
Leonelli, Ariana T.
Petros, Brittany A.
Brock-Fisher, Taylor
Dobbins, Sabrina T.
MacInnis, Bronwyn L.
Capone, Amelia
Littlehale, Nancy
Boucau, Julie
Marino, Caitlin
Barczak, Amy K.
Sabeti, Pardis C.
Springer, Michael
Stephenson, Kathryn E.
author_facet Dai, Eric Y.
Lee, Kannon A.
Nathanson, Audrey B.
Leonelli, Ariana T.
Petros, Brittany A.
Brock-Fisher, Taylor
Dobbins, Sabrina T.
MacInnis, Bronwyn L.
Capone, Amelia
Littlehale, Nancy
Boucau, Julie
Marino, Caitlin
Barczak, Amy K.
Sabeti, Pardis C.
Springer, Michael
Stephenson, Kathryn E.
author_sort Dai, Eric Y.
collection PubMed
description We measured viral kinetics of SARS-CoV-2 Omicron infection in 36 mRNA-vaccinated individuals, 11 of whom were treated with nirmatrelvir-ritonavir (NMV-r). We found that NMV-r was associated with greater incidence of viral rebound compared to no treatment. For those that did not rebound, NMV-r significantly reduced time to PCR conversion.
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spelling pubmed-93871482022-08-19 Viral Kinetics of Severe Acute Respiratory Syndrome Coronavirus 2 (SARS-CoV-2) Omicron Infection in mRNA-Vaccinated Individuals Treated and Not Treated with Nirmatrelvir-Ritonavir Dai, Eric Y. Lee, Kannon A. Nathanson, Audrey B. Leonelli, Ariana T. Petros, Brittany A. Brock-Fisher, Taylor Dobbins, Sabrina T. MacInnis, Bronwyn L. Capone, Amelia Littlehale, Nancy Boucau, Julie Marino, Caitlin Barczak, Amy K. Sabeti, Pardis C. Springer, Michael Stephenson, Kathryn E. medRxiv Article We measured viral kinetics of SARS-CoV-2 Omicron infection in 36 mRNA-vaccinated individuals, 11 of whom were treated with nirmatrelvir-ritonavir (NMV-r). We found that NMV-r was associated with greater incidence of viral rebound compared to no treatment. For those that did not rebound, NMV-r significantly reduced time to PCR conversion. Cold Spring Harbor Laboratory 2022-08-04 /pmc/articles/PMC9387148/ /pubmed/35982651 http://dx.doi.org/10.1101/2022.08.04.22278378 Text en https://creativecommons.org/licenses/by-nc/4.0/This work is licensed under a Creative Commons Attribution-NonCommercial 4.0 International License (https://creativecommons.org/licenses/by-nc/4.0/) , which allows reusers to distribute, remix, adapt, and build upon the material in any medium or format for noncommercial purposes only, and only so long as attribution is given to the creator.
spellingShingle Article
Dai, Eric Y.
Lee, Kannon A.
Nathanson, Audrey B.
Leonelli, Ariana T.
Petros, Brittany A.
Brock-Fisher, Taylor
Dobbins, Sabrina T.
MacInnis, Bronwyn L.
Capone, Amelia
Littlehale, Nancy
Boucau, Julie
Marino, Caitlin
Barczak, Amy K.
Sabeti, Pardis C.
Springer, Michael
Stephenson, Kathryn E.
Viral Kinetics of Severe Acute Respiratory Syndrome Coronavirus 2 (SARS-CoV-2) Omicron Infection in mRNA-Vaccinated Individuals Treated and Not Treated with Nirmatrelvir-Ritonavir
title Viral Kinetics of Severe Acute Respiratory Syndrome Coronavirus 2 (SARS-CoV-2) Omicron Infection in mRNA-Vaccinated Individuals Treated and Not Treated with Nirmatrelvir-Ritonavir
title_full Viral Kinetics of Severe Acute Respiratory Syndrome Coronavirus 2 (SARS-CoV-2) Omicron Infection in mRNA-Vaccinated Individuals Treated and Not Treated with Nirmatrelvir-Ritonavir
title_fullStr Viral Kinetics of Severe Acute Respiratory Syndrome Coronavirus 2 (SARS-CoV-2) Omicron Infection in mRNA-Vaccinated Individuals Treated and Not Treated with Nirmatrelvir-Ritonavir
title_full_unstemmed Viral Kinetics of Severe Acute Respiratory Syndrome Coronavirus 2 (SARS-CoV-2) Omicron Infection in mRNA-Vaccinated Individuals Treated and Not Treated with Nirmatrelvir-Ritonavir
title_short Viral Kinetics of Severe Acute Respiratory Syndrome Coronavirus 2 (SARS-CoV-2) Omicron Infection in mRNA-Vaccinated Individuals Treated and Not Treated with Nirmatrelvir-Ritonavir
title_sort viral kinetics of severe acute respiratory syndrome coronavirus 2 (sars-cov-2) omicron infection in mrna-vaccinated individuals treated and not treated with nirmatrelvir-ritonavir
topic Article
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9387148/
https://www.ncbi.nlm.nih.gov/pubmed/35982651
http://dx.doi.org/10.1101/2022.08.04.22278378
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