New quinoline and isatin derivatives as apoptotic VEGFR-2 inhibitors: design, synthesis, anti-proliferative activity, docking, ADMET, toxicity, and MD simulation studies

New quinoline and isatin derivatives having the main characteristics of VEGFR-2 inhibitors was synthesised. The antiproliferative effects of these compounds were estimated against A549, Caco-2, HepG2, and MDA-MB-231. Compounds 13 and 14 showed comparable activities with doxorubicin against the Caco-...

Descripción completa

Detalles Bibliográficos
Autores principales: Elkaeed, Eslam B., Taghour, Mohammed S., Mahdy, Hazem A., Eldehna, Wagdy M., El-Deeb, Nehal M., Kenawy, Ahmed M., A. Alsfouk, Bshra, Dahab, Mohammed A., Metwaly, Ahmed M., Eissa, Ibrahim H., El-Zahabi, Mohamed A.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Taylor & Francis 2022
Materias:
Research Paper
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9387325/
https://www.ncbi.nlm.nih.gov/pubmed/35975321
http://dx.doi.org/10.1080/14756366.2022.2110869

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9387325/
https://www.ncbi.nlm.nih.gov/pubmed/35975321
http://dx.doi.org/10.1080/14756366.2022.2110869

Ejemplares similares