O-GlcNAc transferase maintains metabolic homeostasis in response to CDK9 inhibition

Co-targeting of O-GlcNAc transferase (OGT) and the transcriptional kinase cyclin-dependent kinase 9 (CDK9) is toxic to prostate cancer cells. As OGT is an essential glycosyltransferase, identifying an alternative target showing similar effects is of great interest. Here, we used a multiomics approac...

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Detalles Bibliográficos
Autores principales: Gondane, Aishwarya, Poulose, Ninu, Walker, Suzanne, Mills, Ian G, Itkonen, Harri M
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Oxford University Press 2022
Materias:
Original Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9387508/
https://www.ncbi.nlm.nih.gov/pubmed/35708495
http://dx.doi.org/10.1093/glycob/cwac038

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9387508/
https://www.ncbi.nlm.nih.gov/pubmed/35708495
http://dx.doi.org/10.1093/glycob/cwac038

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