Imaging of antitubercular dimeric boronic acids at the mycobacterial cell surface by click-probe capture

Dimeric boronic acids kill Mycobacterium tuberculosis (Mtb) by targeting mycobacterial specific extracellular glycans, removing the requirement for a therapeutic agent to permeate the complex cell envelope. Here we report the successful development and use of new ‘clickable’ boronic acid probes as a...

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Detalles Bibliográficos
Autores principales: Guy, Collette S., Tomás, Ruben M. F., Tang, Qiao, Gibson, Matthew I., Fullam, Elizabeth
Formato: Online Artículo Texto
Lenguaje:English
Publicado: The Royal Society of Chemistry 2022
Materias:
Chemistry
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9387567/
https://www.ncbi.nlm.nih.gov/pubmed/35917119
http://dx.doi.org/10.1039/d2cc02407a
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author Guy, Collette S.
Tomás, Ruben M. F.
Tang, Qiao
Gibson, Matthew I.
Fullam, Elizabeth
author_facet Guy, Collette S.
Tomás, Ruben M. F.
Tang, Qiao
Gibson, Matthew I.
Fullam, Elizabeth
author_sort Guy, Collette S.
collection PubMed
description Dimeric boronic acids kill Mycobacterium tuberculosis (Mtb) by targeting mycobacterial specific extracellular glycans, removing the requirement for a therapeutic agent to permeate the complex cell envelope. Here we report the successful development and use of new ‘clickable’ boronic acid probes as a powerful method to enable the direct detection and visualisation of this unique class of cell-surface targeting antitubercular agents.
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spelling pubmed-93875672022-09-08 Imaging of antitubercular dimeric boronic acids at the mycobacterial cell surface by click-probe capture Guy, Collette S. Tomás, Ruben M. F. Tang, Qiao Gibson, Matthew I. Fullam, Elizabeth Chem Commun (Camb) Chemistry Dimeric boronic acids kill Mycobacterium tuberculosis (Mtb) by targeting mycobacterial specific extracellular glycans, removing the requirement for a therapeutic agent to permeate the complex cell envelope. Here we report the successful development and use of new ‘clickable’ boronic acid probes as a powerful method to enable the direct detection and visualisation of this unique class of cell-surface targeting antitubercular agents. The Royal Society of Chemistry 2022-08-02 /pmc/articles/PMC9387567/ /pubmed/35917119 http://dx.doi.org/10.1039/d2cc02407a Text en This journal is © The Royal Society of Chemistry https://creativecommons.org/licenses/by/3.0/
spellingShingle Chemistry
Guy, Collette S.
Tomás, Ruben M. F.
Tang, Qiao
Gibson, Matthew I.
Fullam, Elizabeth
Imaging of antitubercular dimeric boronic acids at the mycobacterial cell surface by click-probe capture
title Imaging of antitubercular dimeric boronic acids at the mycobacterial cell surface by click-probe capture
title_full Imaging of antitubercular dimeric boronic acids at the mycobacterial cell surface by click-probe capture
title_fullStr Imaging of antitubercular dimeric boronic acids at the mycobacterial cell surface by click-probe capture
title_full_unstemmed Imaging of antitubercular dimeric boronic acids at the mycobacterial cell surface by click-probe capture
title_short Imaging of antitubercular dimeric boronic acids at the mycobacterial cell surface by click-probe capture
title_sort imaging of antitubercular dimeric boronic acids at the mycobacterial cell surface by click-probe capture
topic Chemistry
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9387567/
https://www.ncbi.nlm.nih.gov/pubmed/35917119
http://dx.doi.org/10.1039/d2cc02407a
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