Cargando…

Chimeric Antigen Receptor T Cells Targeting Cell Surface GRP78 to Eradicate Acute Myeloid Leukemia

Acute myeloid leukemia (AML) is a serious, life-threatening hematological malignancy. The treatment outcome of relapsed or refractory AML patients remains dismal, and new treatment options are needed. Chimeric antigen receptor (CAR) T cells have been successful in improving the prognosis for B-linea...

Descripción completa

Detalles Bibliográficos
Autores principales:	Yu, Wei, Zhang, Hang, Yuan, Yuncang, Tang, Jie, Chen, Xinchuan, Liu, Ting, Zhao, Xudong
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	Frontiers Media S.A. 2022
Materias:	Cell and Developmental Biology
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9387679/ https://www.ncbi.nlm.nih.gov/pubmed/35990606 http://dx.doi.org/10.3389/fcell.2022.928140

Ejemplares similares

Chimeric antigen receptor T cells targeting cell surface GRP78 efficiently kill glioblastoma and cancer stem cells
por: Wang, Shijie, et al.
Publicado: (2023)

Potential to Eradicate Cancer Stemness by Targeting Cell Surface GRP78
por: Chen, Hsin-Ying, et al.
Publicado: (2022)

Cell surface GRP78-directed CAR-T cells are effective at treating human pancreatic cancer in preclinical models
por: Yuan, Yuncang, et al.
Publicado: (2023)

SOCS3 Negatively Regulates Cardiac Hypertrophy via Targeting GRP78-Mediated ER Stress During Pressure Overload
por: Liu, Shuang, et al.
Publicado: (2021)

Humanized CD30-Targeted Chimeric Antigen Receptor T Cells Exhibit Potent Preclinical Activity Against Hodgkin’s Lymphoma Cells
por: Guo, Jing, et al.
Publicado: (2022)

Leukemia Stem Cell Release From the Stem Cell Niche to Treat Acute Myeloid Leukemia
por: Villatoro, Alicia, et al.
Publicado: (2020)

Regulation of Malignant Myeloid Leukemia by Mesenchymal Stem Cells
por: Tan, Zhenya, et al.
Publicado: (2022)

Doxycycline Inducible Chimeric Antigen Receptor T Cells Targeting CD147 for Hepatocellular Carcinoma Therapy
por: Zhang, Ren-Yu, et al.
Publicado: (2019)

Novel chimeric antigen receptor T cell-based immunotherapy: a perspective for triple-negative breast cancer
por: Geng, Peizhen, et al.
Publicado: (2023)

Polycomb Factor PHF19 Controls Cell Growth and Differentiation Toward Erythroid Pathway in Chronic Myeloid Leukemia Cells
por: García-Montolio, Marc, et al.
Publicado: (2021)

The Bone Marrow Microenvironment Mechanisms in Acute Myeloid Leukemia
por: Pimenta, Débora Bifano, et al.
Publicado: (2021)

OGP46 Induces Differentiation of Acute Myeloid Leukemia Cells via Different Optimal Signaling Pathways
por: Zhao, Min, et al.
Publicado: (2021)

Prognostic characteristics of immune subtypes associated with acute myeloid leukemia and their identification in cell subsets based on single-cell sequencing analysis
por: Lu, Jie, et al.
Publicado: (2022)

Scratching the Surface—An Overview of the Roles of Cell Surface GRP78 in Cancer
por: Chen, Jack, et al.
Publicado: (2022)

Epigenetic Therapies for Acute Myeloid Leukemia and Their Immune-Related Effects
por: Gambacorta, Valentina, et al.
Publicado: (2019)

The Transcriptional Network That Controls Growth Arrest and Macrophage Differentiation in the Human Myeloid Leukemia Cell Line THP-1
por: Gažová, Iveta, et al.
Publicado: (2020)

The miR-203a Regulatory Network Affects the Proliferation of Chronic Myeloid Leukemia K562 Cells
por: He, Jinhua, et al.
Publicado: (2021)

ISM1 protects lung homeostasis via cell-surface GRP78-mediated alveolar macrophage apoptosis
por: Lam, Terence Y. W., et al.
Publicado: (2022)

The Relevance of Transcription Factors in Gastric and Colorectal Cancer Stem Cells Identification and Eradication
por: Pádua, Diana, et al.
Publicado: (2020)

CAR T cells redirected to cell surface GRP78 display robust anti-acute myeloid leukemia activity and do not target hematopoietic progenitor cells
por: Hebbar, Nikhil, et al.
Publicado: (2022)

The Cell Surface GRP78 Facilitates the Invasion of Hepatocellular Carcinoma Cells
por: Zhang, Xiu-Xiu, et al.
Publicado: (2013)

Cell surface GRP78 promotes stemness in normal and neoplastic cells
por: Conner, Clay, et al.
Publicado: (2020)

HDAC8: A Promising Therapeutic Target for Acute Myeloid Leukemia
por: Spreafico, Marco, et al.
Publicado: (2020)

Sequencing-Based Measurable Residual Disease Testing in Acute Myeloid Leukemia
por: Yoest, Jennifer M., et al.
Publicado: (2020)

The Anti-Leukemia Effect of Ascorbic Acid: From the Pro-Oxidant Potential to the Epigenetic Role in Acute Myeloid Leukemia
por: Travaglini, S., et al.
Publicado: (2022)

The Endogenous GRP78 Interactome in Human Head and Neck Cancers: A Deterministic Role of Cell Surface GRP78 in Cancer Stemness
por: Chen, Hsin-Ying, et al.
Publicado: (2018)

Deconvolution of Bulk Gene Expression Profiles with Single-Cell Transcriptomics to Develop a Cell Type Composition-Based Prognostic Model for Acute Myeloid Leukemia
por: Dai, Chengguqiu, et al.
Publicado: (2021)

Real-Time Molecular Monitoring in Acute Myeloid Leukemia With Circulating Tumor DNA
por: Thakral, Deepshi, et al.
Publicado: (2020)

Altered BMP2/4 Signaling in Stem Cells and Their Niche: Different Cancers but Similar Mechanisms, the Example of Myeloid Leukemia and Breast Cancer
por: Guyot, Boris, et al.
Publicado: (2022)

AAV2-mediated GRP78 Transfer Alleviates Retinal Neuronal Injury by Downregulating ER Stress and Tau Oligomer Formation
por: Ha, Yonju, et al.
Publicado: (2018)

Cancer Radiotherapy: Understanding the Price of Tumor Eradication
por: Martin, Olga A., et al.
Publicado: (2020)

Hedgehog/GLI signaling in hematopoietic development and acute myeloid leukemia—From bench to bedside
por: Tesanovic, Suzana, et al.
Publicado: (2022)

Cell surface GRP78 as a biomarker and target for suppressing glioma cells
por: Kang, Bo Ram, et al.
Publicado: (2016)

GRP78-CAR T cell effector function against solid and brain tumors is controlled by GRP78 expression on T cells
por: Ibanez, Jorge, et al.
Publicado: (2023)

The prognostic marker FLVCR2 associated with tumor progression and immune infiltration for acute myeloid leukemia
por: Su, Xiuhua, et al.
Publicado: (2022)

Inflammation and Myeloid Cells in Cancer Progression and Metastasis
por: Deng, Jenying, et al.
Publicado: (2022)

PAK1 Mediates Bone Marrow Stromal Cell-Induced Drug Resistance in Acute Myeloid Leukemia via ERK1/2 Signaling Pathway
por: Li, Banban, et al.
Publicado: (2021)

Dual inhibition of EZH2 and G9A/GLP histone methyltransferases by HKMTI-1-005 promotes differentiation of acute myeloid leukemia cells
por: Sbirkov, Y., et al.
Publicado: (2023)

Modulation of T-cell function by myeloid-derived suppressor cells in hematological malignancies
por: Bhardwaj, Vaishali, et al.
Publicado: (2023)

Molecular subtyping of acute myeloid leukemia through ferroptosis signatures predicts prognosis and deciphers the immune microenvironment
por: Fu, Denggang, et al.
Publicado: (2023)

Cannot write session to /tmp/vufind_sessions/sess_cmo1d8h2jiluia9qfb8uad2gsb