Cargando…

Characterization of Aldosterone-producing Cell Cluster (APCC) at Single-cell Resolution

CONTEXT: The adrenal cortex consists of zona glomerulosa (ZG), fasciculata (ZF), and reticularis. Aldosterone-producing cell clusters (APCCs) that strongly express aldosterone synthase (CYP11B2) are frequently found in adult adrenals and harbor somatic mutations that are also detected in aldosterone...

Descripción completa

Detalles Bibliográficos
Autores principales:	Iwahashi, Norifusa, Umakoshi, Hironobu, Seki, Tsugio, Gomez-Sanchez, Celso E, Mukai, Kuniaki, Suematsu, Makoto, Umezawa, Yuta, Oya, Mototsugu, Kosaka, Takeo, Seki, Masahide, Suzuki, Yutaka, Horiuchi, Yutaka, Ogawa, Yoshihiro, Nishimoto, Koshiro
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	Oxford University Press 2022
Materias:	Clinical Research Article
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9387688/ https://www.ncbi.nlm.nih.gov/pubmed/35796577 http://dx.doi.org/10.1210/clinem/dgac394

Ejemplares similares

FRI166 Characterization of Aldosterone-producing Cell Cluster (APCC) At Single-cell Resolution
por: Iwahashi, Norifusa, et al.
Publicado: (2023)

Human Adrenocortical Remodeling Leading to Aldosterone-Producing Cell Cluster Generation
por: Nishimoto, Koshiro, et al.
Publicado: (2016)

Familial Hyperaldosteronism Type 3 with a Rapidly Growing Adrenal Tumor: An In Situ Aldosterone Imaging Study
por: Takizawa, Nae, et al.
Publicado: (2021)

Diverse pathological lesions of primary aldosteronism and their clinical significance
por: Nishimoto, Koshiro, et al.
Publicado: (2021)

Machine learning based models for prediction of subtype diagnosis of primary aldosteronism using blood test
por: Kaneko, Hiroki, et al.
Publicado: (2021)

Reactive oxygen species induction by cabazitaxel through inhibiting Sestrin-3 in castration resistant prostate cancer
por: Kosaka, Takeo, et al.
Publicado: (2017)

Significance of Discordant Results: between Confirmatory Tests in Diagnosis of Primary Aldosteronism
por: Fukumoto, Tazuru, et al.
Publicado: (2021)

PKM2 under hypoxic environment causes resistance to mTOR inhibitor in human castration resistant prostate cancer
por: Yasumizu, Yota, et al.
Publicado: (2018)

Machine learning-based models for predicting clinical outcomes after surgery in unilateral primary aldosteronism
por: Kaneko, Hiroki, et al.
Publicado: (2022)

OR09-05 Expression of SLC35F1 in the Plasma Membrane of Cells of Aldosterone Producing Cell Clusters (APCCs) and Its Possible Role in Aldosterone Synthesis
por: Goodchild, Emily, et al.
Publicado: (2020)

Transumbilical laparo-endoscopic single site surgery for adrenal cortical adenoma inducing primary aldosteronism: initial experience
por: Miyajima, Akira, et al.
Publicado: (2011)

A Novel Case of Somatic KCNJ5 Mutation in Pediatric-Onset Aldosterone-Producing Adenoma
por: Uchida, Noboru, et al.
Publicado: (2017)

SAT-548 Significance of Adrenal Vein Aldosterone Gradient in the Diagnosis of Unilateral Subtype of Primary Aldosteronism
por: Ogata, Masatoshi, et al.
Publicado: (2020)

A Novel Method: Super-selective Adrenal Venous Sampling
por: Makita, Kohzoh, et al.
Publicado: (2017)

Impact of aldosterone-producing cell clusters on diagnostic discrepancies in primary aldosteronism
por: Kometani, Mitsuhiro, et al.
Publicado: (2018)

Is DHT Production by 5α-Reductase Friend or Foe in Prostate Cancer?
por: Kosaka, Takeo, et al.
Publicado: (2014)

Complete Response to Bicalutamide Withdrawal Prolonged for Almost 2 Years in Patients With Metastatic Prostate Cancer()
por: Hongo, Hiroshi, et al.
Publicado: (2014)

Analysis of cabazitaxel‐resistant mechanism in human castration‐resistant prostate cancer
por: Hongo, Hiroshi, et al.
Publicado: (2018)

Complete response with early introduction of cabazitaxel in a patient with multiple lung metastases of castration-resistant prostate cancer following the early detection of metastases using liquid biopsy: a case report
por: Kosaka, Takeo, et al.
Publicado: (2019)

SAT-551 Sparing Confirmatory Tests in Primary Aldosteronism
por: Umakoshi, Hironobu, et al.
Publicado: (2020)

Reassessment of Urinary Aldosterone Measurement After Saline Infusion in Primary Aldosteronism
por: Kaneko, Hiroki, et al.
Publicado: (2020)

Squamous cell carcinoma of the prostate with SMARCA4 alteration in a Japanese patient
por: Kaneko, Yuta, et al.
Publicado: (2022)

Investigation of the Optimal Dose aPCC in Reversing the Effect of Factor Xa Inhibitors—An In Vitro Study
por: Schultz, Nina Haagenrud, et al.
Publicado: (2021)

Subtype-specific collaborative transcription factor networks are promoted by OCT4 in the progression of prostate cancer
por: Takayama, Ken-ichi, et al.
Publicado: (2021)

Whole Transcriptome Profiling of Adrenocortical Tumors Using Formalin-Fixed Paraffin-Embedded Samples
por: Iwahashi, Norifusa, et al.
Publicado: (2022)

SUN-378 Unilateral Primary Aldosteronism as an Independent Risk Factor for Vertebral Fracture
por: Sakamoto, Ryuichi, et al.
Publicado: (2020)

A Case of Bladder Cancer after Radiation Therapy for Prostate Cancer
por: Kaburaki, Naoto, et al.
Publicado: (2014)

Prognostic significance of grade 3/4 neutropenia in Japanese prostate cancer patients treated with cabazitaxel
por: Kosaka, Takeo, et al.
Publicado: (2018)

Interstitial pneumonitis in a castration-resistant prostate cancer patient receiving cabazitaxel after thoracic radiation therapy: a case report
por: Yanai, Yoshinori, et al.
Publicado: (2019)

Clinically complete response to abiraterone acetate in a patient with metastatic castration‐resistant prostate cancer
por: Yanai, Yoshinori, et al.
Publicado: (2019)

Utility of prophylactic antibiotics for preventing febrile neutropenia during cabazitaxel therapy for castration-resistant prostate cancer
por: Watanabe, Keitaro, et al.
Publicado: (2021)

Discovery of a new candidate drug to overcome cabazitaxel-resistant gene signature in castration-resistant prostate cancer by in silico screening
por: Hongo, Hiroshi, et al.
Publicado: (2021)

Coexistence of bone and vascular disturbances in patients with endogenous glucocorticoid excess
por: Yano, Chieko, et al.
Publicado: (2022)

THU418 Steroid Profiles And Its Implication In Bone Mass And Quality In Premenopausal Women With Adrenal Tumors With Autonomous Cortisol Secretion
por: Nakao, Hiroshi, et al.
Publicado: (2023)

Adrenal steroid metabolites and bone status in patients with adrenal incidentalomas and hypercortisolism
por: Nakao, Hiroshi, et al.
Publicado: (2023)

Brachytherapy seeds as a nidus for urethral stone formation: A case report
por: Kamisawa, Ken, et al.
Publicado: (2019)

Aggressive prostate cancer with somatic loss of the homologous recombination repair gene FANCA: a case report
por: Hongo, Hiroshi, et al.
Publicado: (2020)

Cranial nerve palsy caused by metastasis to the skull base in patients with castration‐resistant prostate cancer: Three case reports
por: Yasumizu, Yota, et al.
Publicado: (2021)

Association of colitis with gut-microbiota dysbiosis in clathrin adapter AP-1B knockout mice
por: Jangid, Aditi, et al.
Publicado: (2020)

Down-regulation of NF kappa B activation is an effective therapeutic modality in acquired platinum-resistant bladder cancer
por: Ito, Yujiro, et al.
Publicado: (2015)

Cannot write session to /tmp/vufind_sessions/sess_efp4ccge4h8h01fth6bhvuq06t