Novel 1-hydroxy phenothiazinium-based derivative protects against bacterial sepsis by inhibiting AAK1-mediated LPS internalization and caspase-11 signaling

Sepsis is a life-threatening syndrome with disturbed host responses to severe infections, accounting for the majority of death in hospitalized patients. However, effective medicines are currently scant in clinics due to the poor understanding of the exact underlying mechanism. We previously found th...

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Detalles Bibliográficos
Autores principales: Yuan, Chuang, Ai, Kelong, Xiang, Menghua, Xie, Chengliang, Zhao, Mingyi, Wu, Ming, Li, Hongli, Wu, Yueren, Cao, Yueqing, Li, Can, Zhong, Yanjun, Pei, Xiaomeng, Law, Helen Ka Wai, Gao, Liqian, Xiao, Qicai, Yang, Xinyu
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Nature Publishing Group UK 2022
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9387894/
https://www.ncbi.nlm.nih.gov/pubmed/35982051
http://dx.doi.org/10.1038/s41419-022-05151-7

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9387894/
https://www.ncbi.nlm.nih.gov/pubmed/35982051
http://dx.doi.org/10.1038/s41419-022-05151-7

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