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Structural insights into the human PA28–20S proteasome enabled by efficient tagging and purification of endogenous proteins
The ability to produce folded and functional proteins is a necessity for structural biology and many other biological sciences. This task is particularly challenging for numerous biomedically important targets in human cells, including membrane proteins and large macromolecular assemblies, hampering...
| Autores principales: | , , , , , , , |
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| Formato: | Online Artículo Texto |
| Lenguaje: | English |
| Publicado: |
National Academy of Sciences
2022
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| Materias: | |
| Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9388094/ https://www.ncbi.nlm.nih.gov/pubmed/35858375 http://dx.doi.org/10.1073/pnas.2207200119 |