Cargando…

Structural basis of higher order oligomerization of KSHV inhibitor of cGAS

Kaposi's sarcoma–associated herpesvirus (KSHV) inhibitor of cyclic GMP–AMP synthase (cGAS) (KicGAS) encoded by ORF52 is a conserved major tegument protein of KSHV and the first reported viral inhibitor of cGAS. In our previous study, we found that KicGAS is highly oligomerized in solution and t...

Descripción completa

Detalles Bibliográficos
Autores principales: Bhowmik, Debipreeta, Tian, Yuan, Wang, Bing, Zhu, Fanxiu, Yin, Qian
Formato: Online Artículo Texto
Lenguaje:English
Publicado: National Academy of Sciences 2022
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9388135/
https://www.ncbi.nlm.nih.gov/pubmed/35939686
http://dx.doi.org/10.1073/pnas.2200285119