Early B cell factor 4 modulates FAS-mediated apoptosis and promotes cytotoxic function in human immune cells

Apoptosis is a genetically regulated program of cell death that plays a key role in immune disease processes. We identified EBF4, a little-studied member of the early B cell factor (EBF) family of transcription factors, in a whole-genome CRISPR screen for regulators of Fas/APO-1/CD95-mediated T cell...

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Detalles Bibliográficos
Autores principales: Kubo, Satoshi, Kataria, Rhea, Yao, Yikun, Gabrielski, Justin Q., Zheng, Lixin, Markowitz, Tovah E., Chan, Waipan, Song, Jian, Boddapati, Arun K., Saeki, Keita, Häupl, Björn, Park, Ann Y., Cheng, Yan H., Cui, Jing, Oellerich, Thomas, Lenardo, Michael J.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: National Academy of Sciences 2022
Materias:
Biological Sciences
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9388157/
https://www.ncbi.nlm.nih.gov/pubmed/35939714
http://dx.doi.org/10.1073/pnas.2208522119

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9388157/
https://www.ncbi.nlm.nih.gov/pubmed/35939714
http://dx.doi.org/10.1073/pnas.2208522119

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