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Chemical zymogens for the protein cysteinome
We present three classes of chemical zymogens established around the protein cysteinome. In each case, the cysteine thiol group was converted into a mixed disulfide: with a small molecule, a non-degradable polymer, or with a fast-depolymerizing fuse polymer (Z(LA)). The latter was a polydisulfide ba...
| Autores principales: | , , , , , , , , , |
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| Formato: | Online Artículo Texto |
| Lenguaje: | English |
| Publicado: |
Nature Publishing Group UK
2022
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| Materias: | |
| Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9388531/ https://www.ncbi.nlm.nih.gov/pubmed/35982075 http://dx.doi.org/10.1038/s41467-022-32609-1 |