Uncovering the roles of dihydropyrimidine dehydrogenase in fatty-acid induced steatosis using human cellular models

Pyrimidine catabolism is implicated in hepatic steatosis. Dihydropyrimidine dehydrogenase (DPYD) is an enzyme responsible for uracil and thymine catabolism, and DPYD human genetic variability affects clinically observed toxicity following 5-Fluorouracil administration. In an in vitro model of fatty...

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Detalles Bibliográficos
Autores principales: Sullivan, Kelly E., Kumar, Sheetal, Liu, Xin, Zhang, Ye, de Koning, Emily, Li, Yanfei, Yuan, Jing, Fan, Fan
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Nature Publishing Group UK 2022
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9388600/
https://www.ncbi.nlm.nih.gov/pubmed/35982095
http://dx.doi.org/10.1038/s41598-022-17860-2

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9388600/
https://www.ncbi.nlm.nih.gov/pubmed/35982095
http://dx.doi.org/10.1038/s41598-022-17860-2

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