Adult re-expression of IRSp53 rescues NMDA receptor function and social behavior in IRSp53-mutant mice

IRSp53 (or BAIAP2) is an abundant excitatory postsynaptic scaffolding/adaptor protein that is involved in actin regulation and has been implicated in autism spectrum disorders, schizophrenia, and attention-deficit/hyperactivity disorder. IRSp53 deletion in mice leads to enhanced NMDA receptor (NMDAR...

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Detalles Bibliográficos
Autores principales: Noh, Young Woo, Yook, Chaehyun, Kang, Jaeseung, Lee, Soowon, Kim, Yeonghyeon, Yang, Esther, Kim, Hyun, Kim, Eunjoon
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Nature Publishing Group UK 2022
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9388611/
https://www.ncbi.nlm.nih.gov/pubmed/35982261
http://dx.doi.org/10.1038/s42003-022-03813-y

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9388611/
https://www.ncbi.nlm.nih.gov/pubmed/35982261
http://dx.doi.org/10.1038/s42003-022-03813-y

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