Estrogen-related receptor gamma regulates mitochondrial and synaptic genes and modulates vulnerability to synucleinopathy

Many studies implicate mitochondrial dysfunction as a key contributor to cell loss in Parkinson disease (PD). Previous analyses of dopaminergic (DAergic) neurons from patients with Lewy-body pathology revealed a deficiency in nuclear-encoded genes for mitochondrial respiration, many of which are tar...

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Detalles Bibliográficos
Autores principales: Fox, S. N., McMeekin, L. J., Savage, C. H., Joyce, K. L., Boas, S. M., Simmons, M. S., Farmer, C. B., Ryan, J., Pereboeva, L., Becker, K., Auwerx, J., Sudarshan, S., Ma, J., Lee, A., Roberts, R. C., Crossman, D. K., Kralli, A., Cowell, R. M.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Nature Publishing Group UK 2022
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9388660/
https://www.ncbi.nlm.nih.gov/pubmed/35982091
http://dx.doi.org/10.1038/s41531-022-00369-w

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9388660/
https://www.ncbi.nlm.nih.gov/pubmed/35982091
http://dx.doi.org/10.1038/s41531-022-00369-w

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