SARS-CoV-2 variants of concern: spike protein mutational analysis and epitope for broad neutralization

Mutations in the spike glycoproteins of SARS-CoV-2 variants of concern have independently been shown to enhance aspects of spike protein fitness. Here, we describe an antibody fragment (V(H) ab6) that neutralizes all major variants including the recently emerged BA.1 and BA.2 Omicron subvariants, wi...

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Detalles Bibliográficos
Autores principales: Mannar, Dhiraj, Saville, James W., Sun, Zehua, Zhu, Xing, Marti, Michelle M., Srivastava, Shanti S., Berezuk, Alison M., Zhou, Steven, Tuttle, Katharine S., Sobolewski, Michele D., Kim, Andrew, Treat, Benjamin R., Da Silva Castanha, Priscila Mayrelle, Jacobs, Jana L., Barratt-Boyes, Simon M., Mellors, John W., Dimitrov, Dimiter S., Li, Wei, Subramaniam, Sriram
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Nature Publishing Group UK 2022
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9388680/
https://www.ncbi.nlm.nih.gov/pubmed/35982054
http://dx.doi.org/10.1038/s41467-022-32262-8

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9388680/
https://www.ncbi.nlm.nih.gov/pubmed/35982054
http://dx.doi.org/10.1038/s41467-022-32262-8

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