Cargando…

SARS-CoV-2 variants of concern: spike protein mutational analysis and epitope for broad neutralization

Mutations in the spike glycoproteins of SARS-CoV-2 variants of concern have independently been shown to enhance aspects of spike protein fitness. Here, we describe an antibody fragment (V(H) ab6) that neutralizes all major variants including the recently emerged BA.1 and BA.2 Omicron subvariants, wi...

Descripción completa

Detalles Bibliográficos
Autores principales:	Mannar, Dhiraj, Saville, James W., Sun, Zehua, Zhu, Xing, Marti, Michelle M., Srivastava, Shanti S., Berezuk, Alison M., Zhou, Steven, Tuttle, Katharine S., Sobolewski, Michele D., Kim, Andrew, Treat, Benjamin R., Da Silva Castanha, Priscila Mayrelle, Jacobs, Jana L., Barratt-Boyes, Simon M., Mellors, John W., Dimitrov, Dimiter S., Li, Wei, Subramaniam, Sriram
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	Nature Publishing Group UK 2022
Materias:	Article
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9388680/ https://www.ncbi.nlm.nih.gov/pubmed/35982054 http://dx.doi.org/10.1038/s41467-022-32262-8

Ejemplares similares

Structural analysis of receptor binding domain mutations in SARS-CoV-2 variants of concern that modulate ACE2 and antibody binding
por: Mannar, Dhiraj, et al.
Publicado: (2021)

Potent and broad neutralization of SARS-CoV-2 variants of concern (VOCs) including omicron sub-lineages BA.1 and BA.2 by biparatopic human VH domains
por: Chen, Chuan, et al.
Publicado: (2022)

Structural and biochemical rationale for enhanced spike protein fitness in delta and kappa SARS-CoV-2 variants
por: Saville, James W., et al.
Publicado: (2022)

Cryo-electron microscopy structures of the N501Y SARS-CoV-2 spike protein in complex with ACE2 and 2 potent neutralizing antibodies
por: Zhu, Xing, et al.
Publicado: (2021)

SARS-CoV-2 Omicron variant: Antibody evasion and cryo-EM structure of spike protein–ACE2 complex
por: Mannar, Dhiraj, et al.
Publicado: (2022)

Potent Neutralization of Omicron and other SARS-CoV-2 Variants of Concern by Biparatopic Human VH Domains
por: Chen, Chuan, et al.
Publicado: (2022)

Structural analysis of receptor engagement and antigenic drift within the BA.2 spike protein
por: Saville, James W., et al.
Publicado: (2023)

Three-Dimensional Visualization of Viral Structure, Entry, and Replication Underlying the Spread of SARS-CoV-2
por: Saville, James W., et al.
Publicado: (2022)

High Potency of a Bivalent Human V(H) Domain in SARS-CoV-2 Animal Models
por: Li, Wei, et al.
Publicado: (2020)

AAA+ ATPase p97/VCP mutants and inhibitor binding disrupt inter-domain coupling and subsequent allosteric activation
por: Caffrey, Brian, et al.
Publicado: (2021)

Glycan reactive anti-HIV-1 antibodies bind the SARS-CoV-2 spike protein but do not block viral entry
por: Mannar, Dhiraj, et al.
Publicado: (2021)

Construction of a Large Size Human Immunoglobulin Heavy Chain Variable (VH) Domain Library, Isolation and Characterization of Novel Human Antibody VH Domains Targeting PD-L1 and CD22
por: Sun, Zehua, et al.
Publicado: (2022)

Incidence and spatial distribution of cases of dengue, from 2010 to 2019: an ecological study
por: de Morais, Petrúcio Luiz Lins, et al.
Publicado: (2020)

Rapid Emergence of Potentially Transmissible Severe Acute Respiratory Syndrome Coronavirus 2 With Resistance to Combination Monoclonal Antibody Therapy
por: Jacobs, Jana L, et al.
Publicado: (2023)

Human Antibody Domains and Fragments Targeting Neutrophil Elastase as Candidate Therapeutics for Cancer and Inflammation-Related Diseases
por: Chu, Xiaojie, et al.
Publicado: (2021)

Enhanced elicitation of potent neutralizing antibodies by the SARS-CoV-2 spike receptor binding domain Fc fusion protein in mice
por: Liu, Xianglei, et al.
Publicado: (2020)

The Antibody Germline/Maturation Hypothesis, Elicitation of Broadly Neutralizing Antibodies Against HIV-1 and Cord Blood IgM Repertoires
por: Prabakaran, Ponraj, et al.
Publicado: (2014)

Epitope Mapping of M36, a Human Antibody Domain with Potent and Broad HIV-1 Inhibitory Activity
por: Wan, Chao, et al.
Publicado: (2013)

Effective killing of cells expressing CD276 (B7-H3) by a bispecific T cell engager based on a new fully human antibody
por: Liu, Xianglei, et al.
Publicado: (2021)

Contribution of Coronavirus-Specific Immunoglobulin G Responses to Complement Overactivation in Patients with Severe Coronavirus Disease 2019( )
por: Castanha, Priscila M S, et al.
Publicado: (2022)

Human Antibody V(H) Domains Targeting GPNMB and VCAM-1 as Candidate Therapeutics for Cancers
por: Chu, Xiaojie, et al.
Publicado: (2023)

Human antibody V(H) domains targeting uPAR as candidate therapeutics for cancers
por: Chu, Xiaojie, et al.
Publicado: (2023)

Potent neutralization of SARS-CoV-2 by human antibody heavy-chain variable domains isolated from a large library with a new stable scaffold
por: Sun, Zehua, et al.
Publicado: (2020)

Chimeric antigen receptor-T cells are effective against CEACAM5 expressing non-small cell lung cancer cells resistant to antibody-drug conjugates
por: Kim, Ye-Jin, et al.
Publicado: (2023)

The genome sequence of the Lesser Broad-bordered Yellow Underwing, Noctua janthe (Borkhausen, 1792)
por: Boyes, Douglas, et al.
Publicado: (2023)

Preclinical assessment of a novel human antibody VH domain targeting mesothelin as an antibody-drug conjugate
por: Sun, Zehua, et al.
Publicado: (2023)

Protocol for constructing large size human antibody heavy chain variable domain (V(H)) library and selection of SARS-CoV-2 neutralizing antibody domains
por: Chen, Chuan, et al.
Publicado: (2021)

Can Broadly Neutralizing HIV-1 Antibodies Help Achieve an ART-Free Remission?
por: Hsu, Denise C., et al.
Publicado: (2021)

Vaccine development during global epidemics: the Zika experience
por: Castanha, Priscila M S, et al.
Publicado: (2020)

A Glimmer of Hope: Recent Updates and Future Challenges in Zika Vaccine Development
por: Castanha, Priscila M. S., et al.
Publicado: (2020)

Biochemical and Structural Characterization of Human Core Elongator and Its Subassemblies
por: Dalwadi, Udit, et al.
Publicado: (2022)

A dendrite in every pie: Myeloid dendritic cells in HIV and SIV infection
por: Wonderlich, Elizabeth R., et al.
Publicado: (2012)

Assessment of Novel Mesothelin-Specific Human Antibody Domain VH-Fc Fusion Proteins-Based PET Agents
por: Sun, Zehua, et al.
Publicado: (2023)

Bispecific Engineered Antibody Domains (Nanoantibodies) That Interact Noncompetitively with an HIV-1 Neutralizing Epitope and FcRn
por: Gong, Rui, et al.
Publicado: (2012)

Broadly protective murine monoclonal antibodies against influenza B virus target highly conserved neuraminidase epitopes
por: Wohlbold, Teddy John, et al.
Publicado: (2017)

The Secret Life of ACE2 as a Receptor for the SARS Virus
por: Dimitrov, Dimiter S
Publicado: (2003)

Virus entry: molecular mechanisms and biomedical applications
por: Dimitrov, Dimiter S.
Publicado: (2004)

Human Monoclonal Antibodies Against HIV and Emerging Viruses
por: Dimitrov, Dimiter S.
Publicado: (2008)

In acute pathogenic SIV infection plasmacytoid dendritic cells are depleted from blood and lymph nodes despite mobilization
por: Barratt‐Boyes, Simon M., et al.
Publicado: (2010)

Broadly Neutralizing Bovine Antibodies: Highly Effective New Tools against Evasive Pathogens?
por: Burke, Matthew J., et al.
Publicado: (2020)

Cannot write session to /tmp/vufind_sessions/sess_r08kjqflls3ee8ulk610cavjas