Iron accumulation typifies renal cell carcinoma tumorigenesis but abates with pathological progression, sarcomatoid dedifferentiation, and metastasis

Iron is a potent catalyst of oxidative stress and cellular proliferation implicated in renal cell carcinoma (RCC) tumorigenesis, yet it also drives ferroptosis that suppresses cancer progression and represents a novel therapeutic target for advanced RCC. The von Hippel Lindau (VHL)/hypoxia-inducible...

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Detalles Bibliográficos
Autores principales: Greene, Christopher J., Attwood, Kristopher, Sharma, Nitika J., Balderman, Benjamin, Deng, Rongia, Muhitch, Jason B., Smith, Gary J., Gross, Kenneth W., Xu, Bo, Kauffman, Eric C.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Frontiers Media S.A. 2022
Materias:
Oncology
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9389085/
https://www.ncbi.nlm.nih.gov/pubmed/35992801
http://dx.doi.org/10.3389/fonc.2022.923043

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9389085/
https://www.ncbi.nlm.nih.gov/pubmed/35992801
http://dx.doi.org/10.3389/fonc.2022.923043

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