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Activating transcription factor 4-dependent hsa-miR-663a transcription mediates mTORC1/p70S6K1 signaling underleucine deprivation

The mechanistic target of rapamycin complex 1 (mTORC1) is involved in nutrient-induced signaling and is a master regulator of cell growth and metabolism. Amino acid-deficient conditions affect mTORC1 activity; however, its upstream regulators warrant further investigation. MicroRNAs are key regulato...

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Detalles Bibliográficos
Autores principales: Yamamura, Junki, Ma, Sihui, Jia, Huijuan, Kato, Hisanori
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Frontiers Media S.A. 2022
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9389164/
https://www.ncbi.nlm.nih.gov/pubmed/35990342
http://dx.doi.org/10.3389/fnut.2022.965771