Comparative structural and dynamics study of free and gRNA-bound FnCas9 and SpCas9 proteins

The introduction of CRISPR/Cas9 based gene editing has greatly accelerated therapeutic genome editing. However, the off-target DNA cleavage by CRISPR/Cas9 protein hampers its clinical translation, hindering its widespread use as a programmable genome editing tool. Although Cas9 variants with better...

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Detalles Bibliográficos
Autores principales: Panda, Gayatri, Ray, Arjun
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Research Network of Computational and Structural Biotechnology 2022
Materias:
Research Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9389198/
https://www.ncbi.nlm.nih.gov/pubmed/36016716
http://dx.doi.org/10.1016/j.csbj.2022.07.041

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9389198/
https://www.ncbi.nlm.nih.gov/pubmed/36016716
http://dx.doi.org/10.1016/j.csbj.2022.07.041

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