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Comparative structural and dynamics study of free and gRNA-bound FnCas9 and SpCas9 proteins
The introduction of CRISPR/Cas9 based gene editing has greatly accelerated therapeutic genome editing. However, the off-target DNA cleavage by CRISPR/Cas9 protein hampers its clinical translation, hindering its widespread use as a programmable genome editing tool. Although Cas9 variants with better...
| Autores principales: | , |
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| Formato: | Online Artículo Texto |
| Lenguaje: | English |
| Publicado: |
Research Network of Computational and Structural Biotechnology
2022
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| Materias: | |
| Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9389198/ https://www.ncbi.nlm.nih.gov/pubmed/36016716 http://dx.doi.org/10.1016/j.csbj.2022.07.041 |