Tumor-specific T cell-mediated upregulation of PD-L1 in myelodysplastic syndrome cells does not affect T-cell killing

The PD-1:PD-L1 axis is a binary interaction that delivers inhibitory signals to T cells, impeding both immune surveillance and response to immunotherapy. Here we analyzed a phenomenon whereby tumor-specific T cells induce PD-L1 upregulation in autologous MDS cells in short-term culture, through a me...

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Detalles Bibliográficos
Autores principales: Ferrari, Valentina, Tarke, Alison, Fields, Hannah, Tanaka, Tiffany N., Searles, Stephen, Zanetti, Maurizio
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Frontiers Media S.A. 2022
Materias:
Oncology
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9389224/
https://www.ncbi.nlm.nih.gov/pubmed/35992887
http://dx.doi.org/10.3389/fonc.2022.915629

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9389224/
https://www.ncbi.nlm.nih.gov/pubmed/35992887
http://dx.doi.org/10.3389/fonc.2022.915629

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