Synthesis of novel benzothiazole derivatives and investigation of their enzyme inhibitory effects against Alzheimer's disease

The use of dual acetylcholinesterase (AChE)–monoamine oxidase B (MAO-B) inhibitors is a new approach in the treatment of Alzheimer disease (AD). In this work, 14 new benzothiazoles (4a–4n) were designed and synthesized. In biological activity studies, the AChE, butyrylcholinesterase (BChE), MAO-A an...

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Detalles Bibliográficos
Autores principales: Karaca, Şevval, Osmaniye, Derya, Sağlık, Begum Nurpelin, Levent, Serkan, Ilgın, Sinem, Özkay, Yusuf, Karaburun, Ahmet Çağrı, Kaplancıklı, Zafer Asım, Gundogdu-Karaburun, Nalan
Formato: Online Artículo Texto
Lenguaje:English
Publicado: The Royal Society of Chemistry 2022
Materias:
Chemistry
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9389372/
https://www.ncbi.nlm.nih.gov/pubmed/36090440
http://dx.doi.org/10.1039/d2ra03803j

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9389372/
https://www.ncbi.nlm.nih.gov/pubmed/36090440
http://dx.doi.org/10.1039/d2ra03803j

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