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Chemical and Enzymatic Methods for Post-Translational Protein–Protein Conjugation

[Image: see text] Fusion proteins play an essential role in the biosciences but suffer from several key limitations, including the requirement for N-to-C terminal ligation, incompatibility of constituent domains, incorrect folding, and loss of biological activity. This perspective focuses on chemica...

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Detalles Bibliográficos
Autores principales: Taylor, Ross J., Geeson, Michael B., Journeaux, Toby, Bernardes, Gonçalo J. L.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: American Chemical Society 2022
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9389620/
https://www.ncbi.nlm.nih.gov/pubmed/35912579
http://dx.doi.org/10.1021/jacs.2c00129