The oral ferroportin inhibitor vamifeport improves hemodynamics in a mouse model of sickle cell disease

Sickle cell disease (SCD) is an inherited hemolytic anemia caused by a single point mutation in the β-globin gene of hemoglobin that leads to synthesis of sickle hemoglobin (HbS) in red blood cells (RBCs). HbS polymerizes in hypoxic conditions, leading to intravascular hemolysis, release of free hem...

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Detalles Bibliográficos
Autores principales: Nyffenegger, Naja, Zennadi, Rahima, Kalleda, Natarajaswamy, Flace, Anna, Ingoglia, Giada, Buzzi, Raphael M., Doucerain, Cédric, Buehler, Paul W., Schaer, Dominik J., Dürrenberger, Franz, Manolova, Vania
Formato: Online Artículo Texto
Lenguaje:English
Publicado: American Society of Hematology 2022
Materias:
Red Cells, Iron, and Erythropoiesis
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9389634/
https://www.ncbi.nlm.nih.gov/pubmed/35714304
http://dx.doi.org/10.1182/blood.2021014716

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9389634/
https://www.ncbi.nlm.nih.gov/pubmed/35714304
http://dx.doi.org/10.1182/blood.2021014716

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