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hUCMSCs reduce theca interstitial cells apoptosis and restore ovarian function in premature ovarian insufficiency rats through regulating NR4A1-mediated mitochondrial mechanisms

BACKGROUND: Human umbilical cord mesenchymal stem cells (hUCMSCs, retrospectively registered) have a lot of promise for treating theca interstitial cells(TICs) dysfunction in premature ovarian insufficiency (POI). The mechanisms, however, are still unknown. METHODS: To examine the therapeutic and fi...

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Detalles Bibliográficos
Autores principales: Luo, Qianqian, Tang, Yu, Jiang, Zhonglin, Bao, Hongchu, Fu, Qiang, Zhang, Hongqin
Formato: Online Artículo Texto
Lenguaje:English
Publicado: BioMed Central 2022
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9389823/
https://www.ncbi.nlm.nih.gov/pubmed/35986315
http://dx.doi.org/10.1186/s12958-022-00992-5