Radiation Cleaved Drug-Conjugate Linkers Enable Local Payload Release

[Image: see text] Conjugation of therapeutic payloads to biologics including antibodies and albumin can enhance the selectively of drug delivery to solid tumors. However, achieving activity in tumors while avoiding healthy tissues remains a challenge, and payload activity in off-target tissues can c...

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Detalles Bibliográficos
Autores principales: Quintana, Jeremy M., Arboleda, David, Hu, Huiyu, Scott, Ella, Luthria, Gaurav, Pai, Sara, Parangi, Sareh, Weissleder, Ralph, Miller, Miles A.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: American Chemical Society 2022
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9390333/
https://www.ncbi.nlm.nih.gov/pubmed/35833631
http://dx.doi.org/10.1021/acs.bioconjchem.2c00174

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9390333/
https://www.ncbi.nlm.nih.gov/pubmed/35833631
http://dx.doi.org/10.1021/acs.bioconjchem.2c00174

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