Utilisation of semiconductor sequencing for detection of actionable fusions in solid tumours

Oncogenic fusions represent compelling druggable targets in solid tumours highlighted by the recent site agnostic FDA approval of larotrectinib for NTRK rearrangements. However screening for fusions in routinely processed tissue samples is constrained due to degradation of nucleic acid as a result o...

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Detalles Bibliográficos
Autores principales: Loddo, Marco, Hardisty, Keeda-Marie, Llewelyn, Alexander, Haddow, Tiffany, Thatcher, Robert, Williams, Gareth
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Public Library of Science 2022
Materias:
Research Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9390944/
https://www.ncbi.nlm.nih.gov/pubmed/35984852
http://dx.doi.org/10.1371/journal.pone.0246778

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9390944/
https://www.ncbi.nlm.nih.gov/pubmed/35984852
http://dx.doi.org/10.1371/journal.pone.0246778

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