RB1 loss triggers dependence on ESRRG in retinoblastoma

Retinoblastoma (Rb) is a deadly childhood eye cancer that is classically initiated by inactivation of the RB1 tumor suppressor. Clinical management continues to rely on nonspecific chemotherapeutic agents that are associated with treatment resistance and toxicity. Here, we analyzed 103 whole exomes,...

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Detalles Bibliográficos
Autores principales: Field, Matthew G., Kuznetsoff, Jeffim N., Zhang, Michelle G., Dollar, James J., Durante, Michael A., Sayegh, Yoseph, Decatur, Christina L., Kurtenbach, Stefan, Pelaez, Daniel, Harbour, J. William
Formato: Online Artículo Texto
Lenguaje:English
Publicado: American Association for the Advancement of Science 2022
Materias:
Biomedicine and Life Sciences
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9390996/
https://www.ncbi.nlm.nih.gov/pubmed/35984874
http://dx.doi.org/10.1126/sciadv.abm8466

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9390996/
https://www.ncbi.nlm.nih.gov/pubmed/35984874
http://dx.doi.org/10.1126/sciadv.abm8466

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