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Charge-based interactions through peptide position 4 drive diversity of antigen presentation by human leukocyte antigen class I molecules

Human leukocyte antigen class I (HLA-I) molecules bind and present peptides at the cell surface to facilitate the induction of appropriate CD8+ T cell-mediated immune responses to pathogen- and self-derived proteins. The HLA-I peptide-binding cleft contains dominant anchor sites in the B and F pocke...

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Detalles Bibliográficos
Autores principales: Jackson, Kyle R, Antunes, Dinler A, Talukder, Amjad H, Maleki, Ariana R, Amagai, Kano, Salmon, Avery, Katailiha, Arjun S, Chiu, Yulun, Fasoulis, Romanos, Rigo, Maurício Menegatti, Abella, Jayvee R, Melendez, Brenda D, Li, Fenge, Sun, Yimo, Sonnemann, Heather M, Belousov, Vladislav, Frenkel, Felix, Justesen, Sune, Makaju, Aman, Liu, Yang, Horn, David, Lopez-Ferrer, Daniel, Huhmer, Andreas F, Hwu, Patrick, Roszik, Jason, Hawke, David, Kavraki, Lydia E, Lizée, Gregory
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Oxford University Press 2022
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9391200/
https://www.ncbi.nlm.nih.gov/pubmed/36003074
http://dx.doi.org/10.1093/pnasnexus/pgac124