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A High-Throughput Fluorescent Turn-On Assay for Inhibitors of DHHC Family Proteins

[Image: see text] As the “writer” enzymes of protein S-acylation, a dynamic and functionally significant post-translational modification (PTM), DHHC family proteins have emerged in the past decade as both key modulators of cellular homeostasis and as drivers of neoplastic, autoimmune, metabolic, and...

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Detalles Bibliográficos
Autores principales: Qiu, Tian, Azizi, Saara-Anne, Brookes, Noah, Lan, Tong, Dickinson, Bryan C.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: American Chemical Society 2022
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9391280/
https://www.ncbi.nlm.nih.gov/pubmed/35816339
http://dx.doi.org/10.1021/acschembio.2c00193