Thymocyte regulatory variant alters transcription factor binding and protects from type 1 diabetes in infants

We recently mapped a genetic susceptibility locus on chromosome 6q22.33 for type 1 diabetes (T1D) diagnosed below the age of 7 years between the PTPRK and thymocyte-selection-associated (THEMIS) genes. As the thymus plays a central role in shaping the T cell repertoire, we aimed to identify the most...

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Detalles Bibliográficos
Autores principales: Sandholm, Niina, Rubio García, Arcadio, Pekalski, Marcin L., Inshaw, Jamie R. J., Cutler, Antony J., Todd, John A.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Nature Publishing Group UK 2022
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9391468/
https://www.ncbi.nlm.nih.gov/pubmed/35986039
http://dx.doi.org/10.1038/s41598-022-18296-4

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9391468/
https://www.ncbi.nlm.nih.gov/pubmed/35986039
http://dx.doi.org/10.1038/s41598-022-18296-4

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