Cargando…

Thymocyte regulatory variant alters transcription factor binding and protects from type 1 diabetes in infants

We recently mapped a genetic susceptibility locus on chromosome 6q22.33 for type 1 diabetes (T1D) diagnosed below the age of 7 years between the PTPRK and thymocyte-selection-associated (THEMIS) genes. As the thymus plays a central role in shaping the T cell repertoire, we aimed to identify the most...

Descripción completa

Detalles Bibliográficos
Autores principales:	Sandholm, Niina, Rubio García, Arcadio, Pekalski, Marcin L., Inshaw, Jamie R. J., Cutler, Antony J., Todd, John A.
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	Nature Publishing Group UK 2022
Materias:	Article
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9391468/ https://www.ncbi.nlm.nih.gov/pubmed/35986039 http://dx.doi.org/10.1038/s41598-022-18296-4

Ejemplares similares

In-depth immunophenotyping data of IL-6R on the human peripheral regulatory T cell (Treg) compartment
por: Ferreira, Ricardo C., et al.
Publicado: (2017)

CD56(bright) natural killer cells preferentially kill proliferating CD4(+) T cells
por: Lee, Mercede, et al.
Publicado: (2023)

Human IL-6R(hi)TIGIT(−) CD4(+) CD127(low)CD25(+) T cells display potent in vitro suppressive capacity and a distinct Th17 profile
por: Ferreira, Ricardo C., et al.
Publicado: (2017)

Global dynamics of stage-specific transcription factor binding during thymocyte development
por: Hosoya, Tomonori, et al.
Publicado: (2018)

Dissection of a Complex Disease Susceptibility Region Using a Bayesian Stochastic Search Approach to Fine Mapping
por: Wallace, Chris, et al.
Publicado: (2015)

Functional genetic variants can mediate their regulatory effects through alteration of transcription factor binding
por: Johnston, Andrew D., et al.
Publicado: (2019)

Alterations in thymocyte populations under conditions of endotoxin tolerance
por: Tao, Yi-Jing, et al.
Publicado: (2021)

Analysis of thymocyte MHC specificity with thymocyte hybridomas
Publicado: (1984)

An anti-DEC-205 monoclonal antibody stimulates binding of thymocytes to rat thymic dendritic cells and promotes apoptosis of thymocytes
por: Majstorović, Ivana, et al.
Publicado: (2014)

Interleukin 4 expressed in situ selectively alters thymocyte development
Publicado: (1991)

Mechanisms Involved in the Binding of Thymocytes to Rat Thymic Dendritic Cells
por: Čolić, Miodrag, et al.
Publicado: (1996)

The thymic medulla is required for Foxp3(+) regulatory but not conventional CD4(+) thymocyte development
por: Cowan, Jennifer E., et al.
Publicado: (2013)

CASCADE: high-throughput characterization of regulatory complex binding altered by non-coding variants
por: Bray, David, et al.
Publicado: (2022)

Alterations in Regulatory T Cell Subpopulations Seen in Preterm Infants
por: Luciano, Angel A., et al.
Publicado: (2014)

Diacylglycerol metabolism attenuates T-cell receptor signaling and alters thymocyte differentiation
por: Almena, M, et al.
Publicado: (2013)

Role of β2 Integrins in the Binding of Thymocytes to Rat Thymic Macrophages
por: Čolić, Miodrag, et al.
Publicado: (1994)

Defects in Thymocyte Differentiation and Thymocyte- Stromal Interactions in the Trisomy 16 Mouse
por: Ewart, Janet L., et al.
Publicado: (1992)

Whole-exome sequencing identifies novel protein-altering variants associated with serum apolipoprotein and lipid concentrations
por: Sandholm, Niina, et al.
Publicado: (2022)

Neonatal and adult recent thymic emigrants produce IL-8 and express complement receptors CR1 and CR2
por: Pekalski, Marcin L., et al.
Publicado: (2017)

Transfer of specific unresponsiveness to organ allografts by thymocytes. Specific unresponsiveness by thymocyte transfer
Publicado: (1979)

The chromosome 6q22.33 region is associated with age at diagnosis of type 1 diabetes and disease risk in those diagnosed under 5 years of age
por: Inshaw, Jamie R. J., et al.
Publicado: (2017)

Alterations in mitochondrial structure and function are early events of dexamethasone-induced thymocyte apoptosis
Publicado: (1995)

Anti‐thymocyte globulin‐mediated immunosenescent alterations of T cells in kidney transplant patients
por: Lee, Ga Hye, et al.
Publicado: (2022)

Epigenetic analysis of regulatory T cells using multiplex bisulfite sequencing
por: Rainbow, Daniel B., et al.
Publicado: (2015)

Genetic and epigenetic background of diabetic kidney disease
por: Sandholm, Niina, et al.
Publicado: (2023)

Mysm1 is required for interferon regulatory factor expression in maintaining HSC quiescence and thymocyte development
por: Huang, X F, et al.
Publicado: (2016)

How Thymocyte Deletion in the Cortex May Curtail Antigen-Specific T-Regulatory Cell Development in the Medulla
por: Wang, Chenglong, et al.
Publicado: (2022)

Requirements for in vitro growth of human thymocytes.
por: Park, S. H., et al.
Publicado: (1991)

Is thymocyte development functional in the aged?
por: Aw, Danielle, et al.
Publicado: (2009)

IL-2 production by self-reactive CD4 thymocytes scales regulatory T cell generation in the thymus
por: Hemmers, Saskia, et al.
Publicado: (2019)

CD45-null transgenic mice reveal a positive regulatory role for CD45 in early thymocyte development, in the selection of CD4+CD8+ thymocytes, and B cell maturation
Publicado: (1996)

Comparison of methods for transcriptome imputation through application to two common complex diseases
por: Fryett, James J., et al.
Publicado: (2018)

Correction: Comparison of methods for transcriptome imputation through application to two common complex diseases
por: Fryett, James J., et al.
Publicado: (2020)

Regulatory SNPs: Altered Transcription Factor Binding Sites Implicated in Complex Traits and Diseases
por: Degtyareva, Arina O., et al.
Publicado: (2021)

HIV infection of thymocytes inhibits IL-7 activity without altering CD127 expression
por: Young, Charlene D, et al.
Publicado: (2011)

Developmental exposure to thyroid disrupting chemical mixtures alters metamorphosis and post-metamorphic thymocyte differentiation
por: McGuire, Connor C., et al.
Publicado: (2022)

CAML regulates Bim-dependent thymocyte death
por: Edgar, Contessa E., et al.
Publicado: (2010)

The role of the Runx transcription factors in thymocyte differentiation and in homeostasis of naive T cells
por: Egawa, Takeshi, et al.
Publicado: (2008)

The role of the Runx transcription factors in thymocyte differentiation and in homeostasis of naive T cells
por: Egawa, Takeshi, et al.
Publicado: (2007)

Upregulation of surface markers on dying thymocytes
Publicado: (1995)

Cannot write session to /tmp/vufind_sessions/sess_aa7husd9bq8ijsju8unb4ksq1k