Perturbing DDR signaling enhances cytotoxic effects of local oncolytic virotherapy and modulates the immune environment in glioma

CAN-2409 is a replication-deficient adenovirus encoding herpes simplex virus (HSV) thymidine kinase (tk) currently in clinical trials for treatment of glioblastoma. The expression of tk in transduced cancer cells results in conversion of the pro-drug ganciclovir into a toxic metabolite causing DNA d...

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Detalles Bibliográficos
Autores principales: Koch, Marilin S., Zdioruk, Mykola, Nowicki, Michal O., Griffith, Alec M., Aguilar-Cordova, Estuardo, Aguilar, Laura K., Guzik, Brian W., Barone, Francesca, Tak, Paul Peter, Schregel, Katharina, Hoetker, Michael S., Lederer, James A., Chiocca, E. Antonio, Tabatabai, Ghazaleh, Lawler, Sean E.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: American Society of Gene & Cell Therapy 2022
Materias:
Original Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9391522/
https://www.ncbi.nlm.nih.gov/pubmed/36032633
http://dx.doi.org/10.1016/j.omto.2022.07.009

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9391522/
https://www.ncbi.nlm.nih.gov/pubmed/36032633
http://dx.doi.org/10.1016/j.omto.2022.07.009

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