An analog sensitive allele permits rapid and reversible chemical inhibition of PKC-3 activity in C. elegans

Engineered analog sensitive kinases provide a highly effective method for acute, controllable, and highly selective inhibition of kinase activity. Here we describe the design and characterization of an analog sensitive allele of the polarity kinase, PKC-3. This allele supports normal function as mea...

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Detalles Bibliográficos
Autores principales: Ng, KangBo, Bland, Tom, Hirani, Nisha, Goehring, Nathan W.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Caltech Library 2022
Materias:
New Methods
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9391946/
https://www.ncbi.nlm.nih.gov/pubmed/35996692
http://dx.doi.org/10.17912/micropub.biology.000610

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9391946/
https://www.ncbi.nlm.nih.gov/pubmed/35996692
http://dx.doi.org/10.17912/micropub.biology.000610

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