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An analog sensitive allele permits rapid and reversible chemical inhibition of PKC-3 activity in C. elegans

Engineered analog sensitive kinases provide a highly effective method for acute, controllable, and highly selective inhibition of kinase activity. Here we describe the design and characterization of an analog sensitive allele of the polarity kinase, PKC-3. This allele supports normal function as mea...

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Detalles Bibliográficos
Autores principales:	Ng, KangBo, Bland, Tom, Hirani, Nisha, Goehring, Nathan W.
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	Caltech Library 2022
Materias:	New Methods
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9391946/ https://www.ncbi.nlm.nih.gov/pubmed/35996692 http://dx.doi.org/10.17912/micropub.biology.000610

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