Nicotinamide activates latent HIV-1 ex vivo in ART suppressed individuals, revealing higher potency than the association of two methyltransferase inhibitors, chaetocin and BIX01294

BACKGROUND: Latent HIV-1 is a major hurdle in obtaining HIV-1 sustained virological remission (SVR). Here we explored histone deacetylation inhibition property of nicotinamide (NAM; n = 17) for the first time in comparison to a combination of methyltransferase inhibitors (MTIs; Chaetocin and BIX0129...

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Detalles Bibliográficos
Autores principales: Samer, Sadia, Arif, Muhammad Shoaib, Giron, Leila Bertoni, Zukurov, Jean Paulo Lopes, Hunter, James, Santillo, Bruna Teresa, Namiyama, Gislene, Galinskas, Juliana, Komninakis, Shirley Vasconcelos, Oshiro, Telma Miyuki, Sucupira, Maria Cecilia, Janini, Luiz Mario, Diaz, Ricardo Sobhie
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Elsevier 2020
Materias:
Original Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9392037/
https://www.ncbi.nlm.nih.gov/pubmed/32105620
http://dx.doi.org/10.1016/j.bjid.2020.01.005

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9392037/
https://www.ncbi.nlm.nih.gov/pubmed/32105620
http://dx.doi.org/10.1016/j.bjid.2020.01.005

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