Inhibition of the cardiac fibroblast-enriched histone methyltransferase Dot1L prevents cardiac fibrosis and cardiac dysfunction

BACKGROUND: Cardiac fibrosis is characterized by excessive extracellular matrix deposition that contributes to compromised cardiac function and potentially heart failure. Disruptor of telomeric silencing 1-like (Dot1L) is the catalytic enzyme required for histone H3K79 methylation which has been dem...

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Detalles Bibliográficos
Autores principales: Xu, Jie, Wang, Jinghuan, Long, Fen, Zhong, Wen, Su, Haibi, Su, Zhenghua, Liu, Xinhua
Formato: Online Artículo Texto
Lenguaje:English
Publicado: BioMed Central 2022
Materias:
Research
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9392317/
https://www.ncbi.nlm.nih.gov/pubmed/35986422
http://dx.doi.org/10.1186/s13578-022-00877-5

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9392317/
https://www.ncbi.nlm.nih.gov/pubmed/35986422
http://dx.doi.org/10.1186/s13578-022-00877-5

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