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Inhibition of the cardiac fibroblast-enriched histone methyltransferase Dot1L prevents cardiac fibrosis and cardiac dysfunction
BACKGROUND: Cardiac fibrosis is characterized by excessive extracellular matrix deposition that contributes to compromised cardiac function and potentially heart failure. Disruptor of telomeric silencing 1-like (Dot1L) is the catalytic enzyme required for histone H3K79 methylation which has been dem...
Autores principales: | Xu, Jie, Wang, Jinghuan, Long, Fen, Zhong, Wen, Su, Haibi, Su, Zhenghua, Liu, Xinhua |
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Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
BioMed Central
2022
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Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9392317/ https://www.ncbi.nlm.nih.gov/pubmed/35986422 http://dx.doi.org/10.1186/s13578-022-00877-5 |
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