Human induced pluripotent stem cell engineering establishes a humanized mouse platform for pediatric low-grade glioma modeling

A major obstacle to identifying improved treatments for pediatric low-grade brain tumors (gliomas) is the inability to reproducibly generate human xenografts. To surmount this barrier, we leveraged human induced pluripotent stem cell (hiPSC) engineering to generate low-grade gliomas (LGGs) harboring...

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Detalles Bibliográficos
Autores principales: Anastasaki, Corina, Chatterjee, Jit, Cobb, Olivia, Sanapala, Shilpa, Scheaffer, Suzanne M., De Andrade Costa, Amanda, Wilson, Anna F., Kernan, Chloe M., Zafar, Ameera H., Ge, Xia, Garbow, Joel R., Rodriguez, Fausto J., Gutmann, David H.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: BioMed Central 2022
Materias:
Research
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9392324/
https://www.ncbi.nlm.nih.gov/pubmed/35986378
http://dx.doi.org/10.1186/s40478-022-01428-2

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9392324/
https://www.ncbi.nlm.nih.gov/pubmed/35986378
http://dx.doi.org/10.1186/s40478-022-01428-2

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