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Human induced pluripotent stem cell engineering establishes a humanized mouse platform for pediatric low-grade glioma modeling

A major obstacle to identifying improved treatments for pediatric low-grade brain tumors (gliomas) is the inability to reproducibly generate human xenografts. To surmount this barrier, we leveraged human induced pluripotent stem cell (hiPSC) engineering to generate low-grade gliomas (LGGs) harboring...

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Detalles Bibliográficos
Autores principales:	Anastasaki, Corina, Chatterjee, Jit, Cobb, Olivia, Sanapala, Shilpa, Scheaffer, Suzanne M., De Andrade Costa, Amanda, Wilson, Anna F., Kernan, Chloe M., Zafar, Ameera H., Ge, Xia, Garbow, Joel R., Rodriguez, Fausto J., Gutmann, David H.
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	BioMed Central 2022
Materias:	Research
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9392324/ https://www.ncbi.nlm.nih.gov/pubmed/35986378 http://dx.doi.org/10.1186/s40478-022-01428-2

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