Synthesis and characterization of two known and one new impurities of dolutegravir: In silico evaluation of certain intermediates against SARS CoV-2 O-ribose methyltransferase (OMTase)

Besides its use against HIV infection the marketed anti-retroviral drug dolutegravir attracted attention as a potential agent against COVID-19 in multiple AI (artificial intelligence) based studies. Due to our interest in accessing the impurities of this drug we report the synthesis and characteriza...

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Detalles Bibliográficos
Autores principales: Garrepalli, Sailaja, Gudipati, Ramesh, Kapavarapu, Ravikumar, Ravindhranath, Kunta, Pal, Manojit
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Elsevier B.V. 2023
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9392419/
https://www.ncbi.nlm.nih.gov/pubmed/36034527
http://dx.doi.org/10.1016/j.molstruc.2022.133992

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9392419/
https://www.ncbi.nlm.nih.gov/pubmed/36034527
http://dx.doi.org/10.1016/j.molstruc.2022.133992

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