Cargando…

Synthesis and characterization of two known and one new impurities of dolutegravir: In silico evaluation of certain intermediates against SARS CoV-2 O-ribose methyltransferase (OMTase)

Besides its use against HIV infection the marketed anti-retroviral drug dolutegravir attracted attention as a potential agent against COVID-19 in multiple AI (artificial intelligence) based studies. Due to our interest in accessing the impurities of this drug we report the synthesis and characteriza...

Descripción completa

Detalles Bibliográficos
Autores principales:	Garrepalli, Sailaja, Gudipati, Ramesh, Kapavarapu, Ravikumar, Ravindhranath, Kunta, Pal, Manojit
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	Elsevier B.V. 2023
Materias:	Article
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9392419/ https://www.ncbi.nlm.nih.gov/pubmed/36034527 http://dx.doi.org/10.1016/j.molstruc.2022.133992

Ejemplares similares

Extraction of Phosphate from Polluted Waters Using Calcium Alginate Beads Doped with Active Carbon Derived from A. aspera Plant as Adsorbent
por: Sujitha, Ravulapalli, et al.
Publicado: (2017)

Preparation, characterization and feasibility analysis of methyl ester of Sesbania seeds oil (MESSO) as alternate liquid dielectrics in distribution transformers
por: Ravulapalli, Sujitha, et al.
Publicado: (2019)

Separation and identification of an impurity from the istradefylline intermediate
por: Xu, Haojie, et al.
Publicado: (2020)

Nitrogen fractionation of certain conventional- and lesser-known by-products for ruminants
por: Mahesh, M.S., et al.
Publicado: (2017)

Preparation of the Key Dolutegravir Intermediate via MgBr(2)-Promoted Cyclization
por: Kong, Jiahui, et al.
Publicado: (2021)

Pyrrolo[2,3-b]quinoxalines in attenuating cytokine storm in COVID-19: their sonochemical synthesis and in silico / in vitro assessment
por: Chemboli, Raviteja, et al.
Publicado: (2021)

Ultrasound assisted Cu-catalyzed Ullmann-Goldberg type coupling-cyclization in a single pot: Synthesis and in silico evaluation of 11H-pyrido[2,1-b]quinazolin-11-ones against SARS-CoV-2 RdRp
por: Manikanttha, Matta, et al.
Publicado: (2023)

Impure Water Makes Impure Ice
Publicado: (1882)

RHAMNETIN IS A BETTER INHIBITOR OF SARS-COV-2 2’-O-METHYLTRANSFERASE THAN DOLUTEGRAVIR: A COMPUTATIONAL PREDICTION
por: Rowaiye, Adekunle B., et al.
Publicado: (2022)

Structural analysis of human 2′-O-ribose methyltransferases involved in mRNA cap structure formation
por: Smietanski, Miroslaw, et al.
Publicado: (2014)

Computational guided drug repurposing for targeting 2′-O-ribose methyltransferase of SARS-CoV-2
por: Sharma, Kedar, et al.
Publicado: (2020)

Molecular dynamic simulations to investigate the structural impact of known drug resistance mutations on HIV-1C Integrase-Dolutegravir binding
por: Chitongo, Rumbidzai, et al.
Publicado: (2020)

The promise of paediatric dolutegravir
por: Golin, Rachel, et al.
Publicado: (2021)

Prediction of Certain Well-Characterized Domains of Known Functions within the PE and PPE Proteins of Mycobacteria
por: Sultana, Rafiya, et al.
Publicado: (2016)

Practical and Scalable Manufacturing Process for the Key Intermediate of Poly(ADP-Ribose) Polymerase Inhibitor Olaparib
por: Chen, Zhaohang, et al.
Publicado: (2022)

Correction: Molecular dynamic simulations to investigate the structural impact of known drug resistance mutations on HIV-1C Integrase-Dolutegravir binding
por: Chitongo, Rumbidzai, et al.
Publicado: (2020)

Gold and platinum in silicon-isolated impurities and impurity complexes
por: Burchard, A, et al.
Publicado: (1996)

Gold and platinum in silicon isolated impurities and impurity complexes
por: Burchard, A, et al.
Publicado: (1996)

The Induction of Tumours of the Subcutaneous Tissues, Liver and Intestine in the Mouse by Certain Dyestuffs and their Intermediates
por: Bonser, Georgiana M., et al.
Publicado: (1956)

Crystal structure of RlmM, the 2′O-ribose methyltransferase for C2498 of Escherichia coli 23S rRNA
por: Punekar, Avinash S., et al.
Publicado: (2012)

The impurity of science
por: Calvin, Melvin
Publicado: (1962)

Impure Glycerine
Publicado: (1868)

Creosote Impurities
Publicado: (1883)

Impurities in Glycerin
por: Bower, Henry
Publicado: (1868)

Impure Air
Publicado: (1859)

Impure Air
Publicado: (1891)

Milk Impurities
Publicado: (1891)

Impure Blood
Publicado: (1884)

Impure Chloroform
Publicado: (1882)

Adverse events of raltegravir and dolutegravir
por: Elzi, Luigia, et al.
Publicado: (2017)

Review of the State of Impurity Occurrences and Impurity Removal Technology in Phosphogypsum
por: Li, Xu, et al.
Publicado: (2023)

CMTr cap-adjacent 2′-O-ribose mRNA methyltransferases are required for reward learning and mRNA localization to synapses
por: Haussmann, Irmgard U., et al.
Publicado: (2022)

Should dolutegravir always be withheld in people with HIV on dolutegravir with incident diabetes mellitus? A case report
por: Mulindwa, Frank, et al.
Publicado: (2023)

Knowledge and perceptions about Dolutegravir and Dolutegravir counselling: a qualitative study among women living with HIV
por: Chapola, John C., et al.
Publicado: (2023)

Should dolutegravir always be withheld in people with HIV on dolutegravir with incident diabetes mellitus? a case report
por: Mulindwa, Frank, et al.
Publicado: (2023)

Electron paramagnetic resonance investigations of isolated impurities and impurity pairs in silicon
por: Burchard, A, et al.
Publicado: (1996)

The mRNA Cap 2′-O-Methyltransferase CMTR1 Regulates the Expression of Certain Interferon-Stimulated Genes
por: Williams, Graham D., et al.
Publicado: (2020)

Effects of boceprevir and telaprevir on the pharmacokinetics of dolutegravir
por: Johnson, Mark, et al.
Publicado: (2014)

The role of dolutegravir in the management of HIV infection
por: Miller, Misty M, et al.
Publicado: (2015)

Psychiatric Symptoms in Patients Receiving Dolutegravir
por: Fettiplace, Anna, et al.
Publicado: (2017)

Cannot write session to /tmp/vufind_sessions/sess_tbib773k4a4gurt9ejfe2cts7g