Cargando…

Schizophrenia-associated differential DNA methylation in brain is distributed across the genome and annotated to MAD1L1, a locus at which DNA methylation and transcription phenotypes share genetic variation with schizophrenia risk

DNA methylation (DNAm), the addition of a methyl group to a cytosine in DNA, plays an important role in the regulation of gene expression. Single-nucleotide polymorphisms (SNPs) associated with schizophrenia (SZ) by genome-wide association studies (GWAS) often influence local DNAm levels. Thus, DNAm...

Descripción completa

Detalles Bibliográficos
Autores principales: McKinney, Brandon C., McClain, Lora L., Hensler, Christopher M., Wei, Yue, Klei, Lambertus, Lewis, David A., Devlin, Bernie, Wang, Jiebiao, Ding, Ying, Sweet, Robert A.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Nature Publishing Group UK 2022
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9392724/
https://www.ncbi.nlm.nih.gov/pubmed/35987687
http://dx.doi.org/10.1038/s41398-022-02071-0