USP10 deubiquitinates Tau, mediating its aggregation

Normal Tau promotes the assembly and stabilization of microtubules, thus, maintaining axon transport. In Alzheimer’s disease (AD), Tau aggregation causes it to lose these above-mentioned functions. However, the molecular mechanism leading to Tau aggregation in AD remains ambiguous. Here, we report t...

Descripción completa

Detalles Bibliográficos
Autores principales: Wei, Zhen, Zeng, Kuan, Hu, Jichang, Li, Xing, Huang, Fang, Zhang, Bin, Wang, Jian-Zhi, Liu, Rong, Li, Hong-Lian, Wang, Xiaochuan
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Nature Publishing Group UK 2022
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9392799/
https://www.ncbi.nlm.nih.gov/pubmed/35987808
http://dx.doi.org/10.1038/s41419-022-05170-4

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9392799/
https://www.ncbi.nlm.nih.gov/pubmed/35987808
http://dx.doi.org/10.1038/s41419-022-05170-4

Ejemplares similares