Long-Circulation and Brain Targeted Isoliquiritigenin Micelle Nanoparticles: Formation, Characterization, Tissue Distribution, Pharmacokinetics and Effects for  Ischemic Stroke

PURPOSE: We designed a novel isoliquiritigenin (ISL) loaded micelle prepared with DSPE-PEG(2000) as the drug carrier modified with the brain-targeting polypeptide angiopep-2 to improve the poor water solubility and low bioavailability of ISL for the treatment of acute ischemic stroke. METHODS: Thin...

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Detalles Bibliográficos
Autores principales: Song, Weitong, Bai, Lu, Yang, Yuya, Wang, Yongchao, Xu, Pingxiang, Zhao, Yuming, Zhou, Xuelin, Li, Xiaorong, Xue, Ming
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Dove 2022
Materias:
Original Research
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9393037/
https://www.ncbi.nlm.nih.gov/pubmed/35999993
http://dx.doi.org/10.2147/IJN.S368528

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9393037/
https://www.ncbi.nlm.nih.gov/pubmed/35999993
http://dx.doi.org/10.2147/IJN.S368528

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