Analysis of Brain Lipids in the Early-Onset Tay–Sachs Disease Mouse Model With the Combined Deficiency of β-Hexosaminidase A and Neuraminidase 3

Introduction: Tay–Sachs disease is an autosomal recessively inherited lysosomal storage disease that results from loss-of-function mutations in the HEXA gene coding β-hexosaminidase A. HEXA gene deficiency affects the central nervous system owing to GM2 ganglioside accumulation in lysosomes resultin...

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Detalles Bibliográficos
Autores principales: Can, Melike, Sengül, Tugce, Demir, Secil Akyildiz, İnci, Orhan K., Basırlı, Hande, Seyrantepe, Volkan
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Frontiers Media S.A. 2022
Materias:
Molecular Biosciences
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9393265/
https://www.ncbi.nlm.nih.gov/pubmed/36003081
http://dx.doi.org/10.3389/fmolb.2022.892248

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9393265/
https://www.ncbi.nlm.nih.gov/pubmed/36003081
http://dx.doi.org/10.3389/fmolb.2022.892248

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