Inhibition of PCSK9 enhances the antitumor effect of PD-1 inhibitor in colorectal cancer by promoting the infiltration of CD8(+) T cells and the exclusion of Treg cells

Immunotherapy especially immune checkpoint inhibitors (ICIs) has brought favorable clinical results for numerous cancer patients. However, the efficacy of ICIs in colorectal cancer (CRC) is still unsatisfactory due to the poor median progression-free survival and overall survival. Here, based on the...

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Detalles Bibliográficos
Autores principales: Wang, Rui, Liu, Hongchuan, He, Peng, An, Duopeng, Guo, Xiaohan, Zhang, Xuyao, Feng, Meiqing
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Frontiers Media S.A. 2022
Materias:
Immunology
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9393481/
https://www.ncbi.nlm.nih.gov/pubmed/36003387
http://dx.doi.org/10.3389/fimmu.2022.947756

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9393481/
https://www.ncbi.nlm.nih.gov/pubmed/36003387
http://dx.doi.org/10.3389/fimmu.2022.947756

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