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Prophylactic and Therapeutic Effect of Kynurenine for Experimental Autoimmune Encephalomyelitis (EAE) Disease

BACKGROUND: The essential amino acid, tryptophan, is predominantly metabolised through the kynurenine pathway (KP) to generate kynurenine, an aryl-hydrocarbon receptor (AhR) pro-ligand that exerts its effects in a ligand-dependent manner. Interaction between kynurenine and the AhR is an effector mec...

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Detalles Bibliográficos
Autores principales: Sundaram, Gayathri, Bessede, Alban, Gilot, David, Staats Pires, Ananda, Sherman, Larry S, Brew, Bruce J, Guillemin, Gilles J
Formato: Online Artículo Texto
Lenguaje:English
Publicado: SAGE Publications 2022
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9393931/
https://www.ncbi.nlm.nih.gov/pubmed/36004319
http://dx.doi.org/10.1177/11786469221118657